GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs73086581 | 1 | rs6052218 | chr20:3970212 | MAVS | chr20:3827449-3856761:+ | -0.23 | -3.56 | 0.000414 | Response to antidepressants in depression |
| THCA | cis | rs73086581 | 1 | rs6052220 | chr20:3970594 | MAVS | chr20:3827449-3856761:+ | -0.22 | -3.49 | 0.00052 | Response to antidepressants in depression |
| THCA | cis | rs9303029 | 1 | rs60529510 | chr17:80407480 | C17orf62 | chr17:80400520-80408694:- | -0.27 | -6.49 | 2.17E-10 | Protein quantitative trait loci |
| THCA | cis | rs9303029 | 1 | rs60529510 | chr17:80407480 | NARF | chr17:80416060-80446141:+ | -0.17 | -3.37 | 0.000798 | Protein quantitative trait loci |
| THCA | cis | rs454422 | 1 | rs6053815 | chr20:5970438 | MCM8 | chr20:5931298-5975829:+ | -0.31 | -6.79 | 3.26E-11 | HIV-1 viral setpoint |
| THCA | cis | rs454422 | 1 | rs6053816 | chr20:5970750 | MCM8 | chr20:5931298-5975829:+ | -0.32 | -7.28 | 1.35E-12 | HIV-1 viral setpoint |
| THCA | cis | rs12435908 | 1 | rs60554055 | chr14:66068285 | LOC645431 | chr14:65877313-65879335:- | -0.53 | -6.89 | 1.79E-11 | Ischemic stroke |
| THCA | cis | rs4785204 | 1 | rs60561577 | chr16:50128572 | HEATR3 | chr16:50099881-50139373:+ | -0.4 | -6.06 | 2.77E-9 | Esophageal cancer (squamous cell) |
| THCA | cis | rs12131428 | 1 | rs60576041 | chr1:162413640 | HSD17B7 | chr1:162760496-162782607:+ | 0.31 | 3.67 | 0.00027 | Discordance in emotional problems in monozygotic twins |
| THCA | cis | rs16895812 | 1 | rs60579513 | chr6:42505472 | PRPH2 | chr6:42664334-42690358:- | -0.29 | -3.91 | 0.000105 | Obesity-related traits |
| THCA | cis | rs1555322 | 1 | rs6058219 | chr20:33859244 | CPNE1 | chr20:34213968-34262539:- | -0.34 | -4.7 | 3.38E-6 | Attention deficit hyperactivity disorder |
| THCA | cis | rs1555322 | 1 | rs6058219 | chr20:33859244 | MMP24 | chr20:33814539-33864804:+ | -0.21 | -3.6 | 0.000346 | Attention deficit hyperactivity disorder |
| THCA | cis | rs6087771 | 1 | rs6058352 | chr20:30269179 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.86 | 0.000126 | Subcortical brain region volumes |
| THCA | cis | rs6087771 | 1 | rs6058465 | chr20:30397691 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.94 | 9.25E-5 | Subcortical brain region volumes |
| THCA | cis | rs6087771 | 1 | rs6058468 | chr20:30406448 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.88 | 0.000118 | Subcortical brain region volumes |